Mechanisms and bioactive compounds of Ci Bai Capsule remain unclear

Determine the molecular mechanisms by which Ci Bai Capsule increases white blood cell counts and identify the specific bioactive compounds within Ci Bai Capsule responsible for mitigating radiation-induced leukopenia.

Background

Ci Bai Capsule is a traditional Chinese medicine formula reported to elevate white blood cell levels in contexts such as radiation-induced leukopenia. Despite clinical observations of benefit, the specific molecular mechanisms and the particular active compounds driving these effects have not been conclusively established. Clarifying these mechanisms and identifying the responsible compounds would support mechanistic understanding, optimize dosing and composition, and improve clinical translation.

References

CB has been reported to enhance white blood cell levels; however, its mechanisms and bioactive compounds remain unclear.

— Network Pharmacology Reveals HSPA1A/BST2 as Potential Targets of Ci Bai Capsule's Active Compounds Intervening in Leukopenia  (2506.12107 - Zhang et al., 13 Jun 2025) in Abstract